Changes in Blood Lipoproteins, Inflammation Response and Tissue Damage After a Single Bout of Exhaustive Exercise
Keywords:Lipoprotein, creatine kinase, lactate dehydrogenase, C-reactive protein, neutrophils, 脂蛋白膽固醇, 肌酸激酶, 乳酸脱氫酶, C反應蛋白, 嗜中性球
LANGUAGE NOTE | Document text in Chinese; abstract also in English.
The objective of this study was to determine the effects on plasma lipoproteins, inflammation response and tissue-damage markers level during their recovery following exhaustive run. These biochemical concentrations were measured before 30 min, immediately after, and 30 min, 1hr, 2hr, 24hr, 48hr, 72hr after an exhaustive run on treadmill in 15 health male subjects with 80%VO2max intensity. The result of one-way ANOVA with measure repeated analysis indicated that there were no significant changes in low-density lipoprotein cholesterol post run, and high-density lipoprotein cholesterol level was remain significant elevated (by 18%) until 2hr post run. The inflammatory marker of C-reactive protein level was significant elevated (by 42%) immediately and returned to baseline post 0.5hr. The neutrophils ratio remain significant increased (by 51%) during 0.5hr until 2hr and returned to baseline post 24hr. The tissue-damage markers were remain elevated by 23% immediately until 2hr in lactate dehydrogenase and only reach to peak (by 108%) significantly post 24hr in creatine kinase. It is concluded that an exhaustive exercise could induce the delay-onset damage and transient inflammatory response in tissue, and have enough rest or suitable antioxidant supplements for recovery.
目的：本研究旨在探討單次衰竭運動後恢復期對於血脂蛋白濃度變化與發炎損傷指標之影響。方法：受試者為15名健康男性(年齡22.8 ± 0.89歲，體重67. ± 1.81公斤)，以高強度(80%VO2max)的固定負荷運動至衰竭，並於運動前30分鐘、運動後立即、0.5hr、lhr、2hr、24hr、48hr、72hr等時間點靜脈採血進行生化值分析。結果：以單因子相依樣本變異數分析顯示，低密度脂蛋白膽固醇(low density lipoprotein-cholesterol, LDL-C)在運動後均無明顯變化；而高密度脂蛋白膽固醇(high density lipoprotein-cholesterol, HDL-C)則在衰竭運動後2hr明顯持續增加約18.3% (p < .05)；發炎指標：C-反應蛋白(C-reactive protein, CRP)於衰竭後立即顯著上升約42%，隨即0.5hr後恢復。嗜中性球比例(neutrophils, net-s%)在運動後0.5hr至2hr持續增加約51%，於24hr之後恢復。組織損傷情形，乳酸脱氫酶(lactate dehydrogenase, LDH)活性在衰竭後立即至2hr期間顯著增加約23%，而肌酸激酶(creatine kinase, CK)活性則在24hr後才明顯增加約108%的峰值反應。結論：本研究血脂蛋白與發炎、損傷等生化反應結果，意味著單次衰竭運動後可能誘發體內組織的延遲性損傷與組織的短暫發炎反應，需要有足夠的休息時間或運用適當的抗氧化增補劑來進行運動恢復。
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